Circulating biological markers of obesity: towards a systems approach

The pathological processes associated with obesity are based on impaired energy homeostasis, as well excessive endocrine and paracrine activity of adipose tissue, leading to inflammation hormonal imbalance, which is accompanied by the secretion a wide range compounds affecting key body processes. One indirect methods for assessing tissue abnormalities measurement concentration cytokines, growth factors, class specific — adipokines tissue. study circulating biomarkers makes it possible assess their association risk complications, metabolic obesity, other clinical functional features. Such markers include (leptin, adiponectin, apelin, resistin, omentin, visfatin, chemerin, lipocalin, etc.), biomarkers, heat shock proteins, discussed in detail this review context use concomitant diseases.